In a pot large enough to hold the pears, place the wine, sugar, saffron, ginger, vanilla bean and salt. Bring to a boil over medium heat.
Meanwhile, peel and cut the pears in half. Using a melon baller, scoop out the core.
With a small paring knife, remove the inner part of the stalk, leaving the outer stem intact.
Add the pears and lower the heat. They should be covered with the cooking liquid.
Cover and poach gently for 10–15 minutes, turning them over occasionally to make sure they color evenly. If desired, you can place a circle of parchment paper on top of the syrup to make sure the pears remain beneath the liquid.
Simmer until pears are soft when pierced with a knife.
Drain and transfer pears to a serving dish or container. If you like a heavier syrup, reduce it until lightly thickened.
Combine pears with syrup and allow to cool before serving. Keeps refrigerated up to a week. Serves 4.